Biological Activity
Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
Technical Data
| M. Wt | 730.97 |
| Formula | C45H62O8 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 144337-18-8 |
| PubChem ID | 9853400 |
| InChI Key | CEJAYJCUSZHYDS-UHFFFAOYSA-N |
| Smiles | OC1=C(C2CC(C4=CC=C(O)C=C4)OC3=C2C=CC(O)=C3)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 73.1 | 100 | |
| ethanol | 73.1 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 730.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.37 mL | 6.84 mL | 13.68 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.37 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.27 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Miyake et al (1993) Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br.J.Pharmacol. 110 447 PMID: 8220906
Miyake et al (1994) Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 253 155 PMID: 8013541
Hamaguchi et al (2003) Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation. Biochim.Biophys.Acta 1635 37 PMID: 14642775
Keywords: YM 26734, supplier, Secretory, phospholipases, A2, sPLA2, inhibitors, inhibits, Esterases, YM26734, Phospholipases, Phospholipases, Tocris Bioscience
