Biological Activity
Derivative of the mGlu1-selective antagonist YM 298198 (Cat. No. 2448).
Licensing Information
Sold with the permission of Astellas Pharma Inc.
Technical Data
| M. Wt | 364.89 |
| Formula | C17H20N4OS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1177767-57-5 |
| PubChem ID | 16759180 |
| InChI Key | SWKZWXJQIDXGLX-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(SC2=NC3=CC=C(N)C=C3N12)C(=O)NC1CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.24 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 364.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.7 mL | 27.41 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.48 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kohara et al (2005) Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabo J.Pharmacol.Exp.Ther. 315 163 PMID: 15976016
Keywords: Desmethyl-YM 298198, supplier, Derivative, mGlu1, mGluR1, antagonists, YM, 298198, Group, I, Receptors, Glutamate, Metabotropic, Desmethyl-YM298198, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
