Biological Activity
Orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).
Licensing Information
(Sold with the permission of Astellas Pharma Inc.)
Technical Data
| M. Wt | 354.2 |
| Formula | C16H12BrN5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 148869-05-0 |
| PubChem ID | 177865 |
| InChI Key | GGPPBTSXFROGAE-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.42 | 100 | |
| ethanol | 8.86 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 354.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.12 mL | 28.23 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.65 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871 PMID: 8904814
Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265 PMID:
Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189 PMID:
Keywords: YM 511, supplier, Potent, aromatase, CYP19, inhibitors, inhibits, Cytochrome, P450, ERR, Estrogen, Receptors, YM511, Cytochrome, P450, Estrogen, and, Related, Receptors, Cytochrome, P450, Tocris Bioscience
