Biological Activity
Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.
Licensing Information
Sold with the permission of Astellas Pharma Inc.
Technical Data
| M. Wt | 309.67 |
| Formula | C11H7N5O4.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 154164-30-4 |
| PubChem ID | 5486547 |
| InChI Key | UMLFDVOHVJPDIZ-UHFFFAOYSA-N |
| Smiles | O=C(N2)C(NC1=C2C=C(N3C=NC=C3)C([N+]([O-])=O)=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.1 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 309.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.23 mL | 16.15 mL | 32.29 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.46 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.23 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ohmori et al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467 PMID: 8120865
Umemura et al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61 PMID: 9409705
Nakano et al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983 PMID: 11589513
Keywords: YM 90K hydrochloride, supplier, Selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, YM90K, hydrochloride, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
