Biological Activity
PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.
Compound Libraries
YZ9 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 234.2 |
| Formula | C12H10O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6093-71-6 |
| PubChem ID | 5289613 |
| InChI Key | IETDBZQIWIJQJG-UHFFFAOYSA-N |
| Smiles | O=C2C(C(OCC)=O)=CC1=CC=C(O)C=C1O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.71 | 50 | |
| ethanol | 4.68 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 234.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.27 mL | 21.35 mL | 42.7 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.54 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Seo et al (2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6 e24179 PMID: 21957443
Keywords: YZ9, supplier, PFKFB3, inhibitors, inhibits, phosphofructo, kinase, fructose, bifunctional, enzymes, growth, cancer, glycolysis, warburg, PFKFB3, PFKFB3, Tocris Bioscience
