Biological Activity
More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.
Technical Data
| M. Wt | 244.24 |
| Formula | C4H6N2O2S.H2SO4 |
| Storage | Store at RT |
| CAS Number | 371962-01-5 |
| PubChem ID | 90479730 |
| InChI Key | UWVNHPNVOMFDHW-ODZAUARKSA-N |
| Smiles | OS(O)(=O)=O.NC(=N)SC=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 10 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.94 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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References
References are publications that support the products' biological activity.
Allan et al (1986) Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 88 379 PMID: 3015310
Holden-Dye and Walker (1988) ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 95 3 PMID: 2851353
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Keywords: ZAPA sulfate, supplier, GABAC, antagonists, agonists, low, affinity, GABAA, receptors, GABAA, Receptors, GABAA-rho, Receptors, GABAA, Receptors, Tocris Bioscience
