Biological Activity
β3-adrenoceptor agonist. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 351.83 |
| Formula | C18H21NO4.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 178600-17-4 |
| PubChem ID | 158793 |
| InChI Key | KCEFVYIWOQSJCH-LMOVPXPDSA-N |
| Smiles | Cl[H].O[C@@H](CNCCOC1=CC=C(CC(O)=O)C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.8 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 351.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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References
References are publications that support the products' biological activity.
Brawley et al (2000) Role of endothelium/nitric oxide in atypical β-adrenoceptor-mediated relaxation in rat isolated aorta. Eur.J.Pharmacol. 398 285 PMID: 10854841
Kozlowska et al (2003) Atypical β-adrenoceptors, different from β3-adrenoceptors, relax the rat isolated mesenteric artery. Br.J.Pharmacol. 140 3 PMID: 12967929
Trayhurn et al (1996) Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the β3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem.Biophys.Res.Comm. 228 605 PMID:
Keywords: ZD 2079, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, ZD2079, AstraZeneca, Adrenergic, Beta-3, Receptors, Adrenergic, Beta-3, Receptors, Tocris Bioscience
