Biological Activity
β3-adrenoceptor agonist. Active metabolite ICI 215,001 hydrochloride (Cat. No. 0929) also available.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 454.95 |
| Formula | C22H30N2O6.HCl |
| Storage | Store at RT |
| CAS Number | 129689-28-7 |
| PubChem ID | 9890216 |
| InChI Key | KCAMZVQSGDBGGF-FERBBOLQSA-N |
| Smiles | O[C@H](COC2=CC=CC=C2)CNCCOC1=CC=C(OCC(NCCOC)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.49 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 454.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 10.99 mL | 21.98 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
on-line. Please contact Customer Service
References
References are publications that support the products' biological activity.
Growcott et al (1993) Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum. Br.J.Pharmacol. 109 1212 PMID: 8104647
Savontaus et al (1998) Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance. Eur.J.Pharmacol. 347 265 PMID: 9653893
How (1993) β3-Adrenergic agonists. Drugs Future 18 529 PMID:
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