Biological Activity
Sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
ZD 7288 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 292.81 |
| Formula | C15H21ClN4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 133059-99-1 |
| PubChem ID | 123983 |
| InChI Key | DUWKUHWHTPRMAP-UHFFFAOYSA-N |
| Smiles | [Cl-].CCN(C1=CC=CC=C1)C1=CC(NC)=[N+](C)C(C)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.28 | 100 | |
| water | 29.28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 292.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.08 mL | 34.15 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.83 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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References
References are publications that support the products' biological activity.
BoSmith et al (1993) Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br.J.Pharmacol. 110 343 PMID: 7693281
Green et al (1996) Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder. Br.J.Pharmacol. 119 1509 PMID: 8982495
Harris and Constanti (1995) Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J.Neurophysiol. 74 2366 PMID: 8747199
Klar et al (2003) Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices. Naunyn Schmiedebergs Arch.Pharmacol. 367 422 PMID: 12690435
Keywords: ZD 7288, supplier, Sino-atrial, node, function, modulators, If, inhibitors, inhibits, Channel, VDAC, ZD7288, ICID7288, AstraZeneca, HCN, ICI, D7288, HCN, Channels, HCN, Channels, Tocris Bioscience
