BiologicalActivity
Novel,cell-permeableinhibitorofproteinkinaseMζ(PKMζ),aconstitutivelyactive,atypicalPKCisozymeinvolvedinLTPmaintenance.SelectivelyblocksPKMζ-inducedsynapticpotentiationinhippocampalslicesinvitro.Reverseslate-phaseLTP(IC50=1-2.5μM)andproducespersistentlossof1-day-oldspatialmemoryfollowingcentraladmiNISTrationinvivo.Controlandbiotinylatedpeptides(Cat.Nos.3215and3290)alsoavailable.
TechnicalData
| M.Wt | 1982.4 |
| Formula | C90H154N30O17 |
| Sequence | SIYRRGARRWRKL (Modifications:Ser-1=Myr-Ser) |
| Storage | Desiccateat-20°C |
| CASNumber | 863987-12-6 |
| PubChemID | 16156119 |
| InChIKey | CRKARHQCXWSUMV-HOHDCHNJSA-N |
| Smiles | [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1982.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.5mL | 2.52mL | 5.04mL |
| 5mM | 0.1mL | 0.5mL | 1.01mL |
| 10mM | 0.05mL | 0.25mL | 0.5mL |
| 50mM | 0.01mL | 0.05mL | 0.1mL |
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