Biological Activity
Potent and highly selective A2A adenosine antagonist, with a pA2 of 9.02 for A2A receptors in guinea pig cardiac vasculature and selectivities of 1000, 91 and 500,000 over A1, A2B and A3 sites respectively. Active in vivo.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
ZM 241385 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 337.34 |
| Formula | C16H15N7O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 139180-30-6 |
| PubChem ID | 176407 |
| InChI Key | PWTBZOIUWZOPFT-UHFFFAOYSA-N |
| Smiles | NC1=NC(NCCC2=CC=C(O)C=C2)=NC2=NC(=NN12)C1=CC=CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.73 | 100 | |
| ethanol | 1.69 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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References
References are publications that support the products' biological activity.
Keddie et al (1996) In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist. Eur.J.Pharmacol. 301 107 PMID: 8773453
Poucher et al (1995) The in vitro pharmacology of ZM 241385, a potent, non-xanthine, A2a selective adenosine receptor antagonist. Br.J.Pharmacol. 115 1096 PMID: 7582508
Poucher et al (1996) Pharmacodynamics of ZM 241385, a potent A2a adenosine receptor antagonist, after enteric administration in rat, cat and dog. J.Pharm.Pharmacol. 48 601 PMID: 8832494
Keywords: ZM 241385, supplier, Potent, selective, A2A, antagonist, Receptors, adenosines, ZM241385, AstraZeneca, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience
