BiologicalActivity
Potentandselectiveinhibitorofhumanvascularendothelialgrowthfactorreceptor2(VEGFR-2/KDR)activity.SelectivelyinhibitsVEGFR-2(IC50=2nM)overVEGFR-1andarangeofotherreceptortyrosinekinasessuchasPDGFRβ,FGFR1,EGFRanderbB2(IC50>50μM).InhibitsVEGF-A-inducedendothelialcellproliferationinvitro(IC50=8nM).
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
CompoundLibraries
ZM323881hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 411.86 |
| Formula | C22H18FN3O2.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 193000-39-4 |
| PubChemID | 22624897 |
| InChIKey | AVRHWGLIYGJSOD-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.59 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight411.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.43mL | 12.14mL | 24.28mL |
| 5mM | 0.49mL | 2.43mL | 4.86mL |
| 10mM | 0.24mL | 1.21mL | 2.43mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
