BiologicalActivity
Potent,selectiveinhibitorofc-Rafinvitro(IC50=70nMforinhibitionofhumanc-Raf).Shows10-foldselectivityoverB-Raf.AlsoinhibitsSAPK2/p38(IC50=2μM).Selectiveover17otherproteinkinasesincludingPKA,PKC,p42MAPK,CDK1andSAPK1/JNK(upto50μM).AlsoavailableaspartoftheMAPKCascadeInhibitorTocriset™.
LicensingInformation
SoldwiththepermissionofAstraZenecaLtd
CompoundLibraries
ZM336372isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 389.45 |
| Formula | C23H23N3O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 208260-29-1 |
| PubChemID | 5311006 |
| InChIKey | SCJNCDSAIRBRIA-DOFZRALJSA-N |
| Smiles | CN(C)C1=CC(=CC=C1)C(=O)NC1=CC=C(C)C(NC(=O)C2=CC=C(O)C=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight389.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.84mL | 25.68mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.28mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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ProductDatasheets
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