BiologicalActivity
Novel,selectiveATP-competitiveinhibitorofAuroraBkinaseinvitro(IC50valuesare50,250and1000nMforAuroraB,CandAkinasesrespectively).Selectiveoverarangeofotherkinasesincludingcdk1andPLK1(IC50>10μM).Inhibitscelldivisionanddisplaysselectivetoxicitytowardsproliferatingtumorcellsversusnon-dividingcells.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
CompoundLibraries
ZM447439isalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 513.59 |
| Formula | C29H31N5O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 331771-20-1 |
| PubChemID | 9914412 |
| InChIKey | OGNYUTNQZVRGMN-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3)N=CN=C2C=C1OCCCN1CCOCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.36 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight513.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.95mL | 9.74mL | 19.47mL |
| 5mM | 0.39mL | 1.95mL | 3.89mL |
| 10mM | 0.19mL | 0.97mL | 1.95mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
