Biological Activity
Phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
Compound Libraries
Zardaverine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 268.22 |
| Formula | C12H10F2N2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 101975-10-4 |
| PubChem ID | 5723 |
| InChI Key | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
| Smiles | COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 268.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Galvan and Schudt (1990) Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle. Naunyn Schmiedebergs Arch.Pharmacol. 342 221 PMID: 1700309
Kilian et al (1989) Is phosphodiesterase inhibition a relevant bronchospasmolytic principle? Agents Actions Suppl. 28 331 PMID: 2683636
Keywords: Zardaverine, supplier, PDE3/4, inhibitors, inhibits, Phosphodiesterases, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
