Biological Activity
Mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.
Technical Data
| M. Wt | 318.36 |
| Formula | C18H22O5 |
| Storage | Store at -20°C |
| CAS Number | 17924-92-4 |
| PubChem ID | 5281576 |
| InChI Key | MBMQEIFVQACCCH-QBODLPLBSA-N |
| Smiles | O=C(C1=C(O)C=C(O)C=C1/C=C/CCC2)O[C@@H](C)CCCC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.84 | 100 | |
| ethanol | 31.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 318.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.71 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kuiper et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 4252 PMID: 9751507
Khosrokhavar et al (2009) Effects of zearalenone and α-Zearalenol in comparison with Raloxifene on T47D cells. Toxicol.Mech.Methods 19 246 PMID: 19730705
Takemura et al (2007) Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J.Steroid Biochem.Molec.Biol. 103 170 PMID:
Keywords: Zearalenone, supplier, estrogen, receptor, ER, ligands, mycotoxins, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
