BiologicalActivity
Sodium-hydrogenexchangerisoform1(NHE1)inhibitorthatdisplaysselectivityoverotherNHEisoforms(Kivaluesare14,2200and220000nMforhumanNHE1,humanNHE2andratNHE3respectively).InhibitsNHE1dependent22Na+uptakeinvitro(IC50=14nM)andprovidescardioprotectionfrommyocardialischemicinjuryinvivo(EC50=0.25nM).AlsoinhibitsMMP2/9activityandinvasioninbreastcancercells.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc
CompoundLibraries
ZoniporidedihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 393.27 |
| Formula | C17H16N6O.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 241799-10-0 |
| PubChemID | 22267855 |
| InChIKey | ARZNPJAGKWHEHT-UHFFFAOYSA-N |
| Smiles | O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.33 | 100 | |
| water | 3.93 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight393.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.54mL | 12.71mL | 25.43mL |
| 5mM | 0.51mL | 2.54mL | 5.09mL |
| 10mM | 0.25mL | 1.27mL | 2.54mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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ProductDatasheets
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