Biological Activity
Nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.
Technical Data
| M. Wt | 356.85 |
| Formula | C23H17ClN2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 178946-89-9 |
| PubChem ID | 5302583 |
| InChI Key | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.69 | 100 | |
| ethanol | 35.69 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 356.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 14.01 mL | 28.02 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470
De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541
Keywords: C-DIM 12, supplier, C-DIM12, Nurr1, activators, activates, NF-KB, NK-kappaB, NF-κB, signaling, signalling, orally, bioavailable, neuroprotective, neuroinflammation, Other, Nuclear, Receptors, NF-kB/IkB, Other, Nuclear, Receptors, Tocris Bioscience
