BiologicalActivity
Potentglycogensynthasekinase-3(GSK-3)inhibitor(Ki=0.6nMforGSK-3αandGSK-3β).Displayshighselectivity(>50-fold)forGSK-3overapanelofotherkinasestested,includingCDKfamilymembers.Decreasesphosphorylationofmicrotubule-associatedproteinTauinvitro;protectsratprimarycorticalneuronsagainstβamyloidandglutamatechallenge.Brainpenetrant.
CompoundLibraries
A1070722isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 362.31 |
| Formula | C17H13F3N4O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1384424-80-9 |
| PubChemID | 49830684 |
| InChIKey | VQPBIJGXSXEOCU-UHFFFAOYSA-N |
| Smiles | O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.23 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight362.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.76mL | 13.8mL | 27.6mL |
| 5mM | 0.55mL | 2.76mL | 5.52mL |
| 10mM | 0.28mL | 1.38mL | 2.76mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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ProductDatasheets
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