BiologicalActivity
Potent,reversIBLeAMP-activatedproteinkinase(AMPK)activator(EC50=0.8μM)thatdisplaysselectivitytowardsβ1subunit-containingheterotrimers.Inhibitsfattyacidsynthesis(IC50=3.2μM)anddecreasesplasmaglucoseandtriglyceridelevelsinvivo.Alsoinhibitsproliferationofmesenchymalstemcells,andimpedesreprogrammingofmouseembryonicfibroblaststoiPSCs.Activatesautophagy.
CompoundLibraries
A769662isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 360.39 |
| Formula | C20H12N2O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 844499-71-4 |
| PubChemID | 54708532 |
| InChIKey | CTESJDQKVOEUOY-UHFFFAOYSA-N |
| Smiles | OC(C1=C(N3)SC=C1C2=CC=C(C4=CC=CC=C4O)C=C2)=C(C#N)C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 | |
| ethanol | 3.6 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.87mL | 27.75mL |
| 5mM | 0.55mL | 2.77mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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