Biological Activity
Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.
Technical Data
| M. Wt | 320.38 |
| Formula | C20H20N2O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 861119-08-6 |
| PubChem ID | 11461365 |
| InChI Key | WUJHMDPPANTBTQ-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C=CC(N4CC(CN(C)C5)C5C4)=C3)OC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 1.6 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054 PMID: 18157163
Keywords: A 844606, supplier, A844606, nicotinic, acetylcholine, receptors, alpha7, a7, agonists, nAChR, α7, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
