Biological Activity
High affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.
Technical Data
| M. Wt | 237.13 |
| Formula | C9H12N2O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 174740-86-4 |
| PubChem ID | 10399247 |
| InChI Key | GVEVDINKRFDXFP-JZGIKJSDSA-N |
| Smiles | [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.71 | 100 | |
| water | 23.71 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 237.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.09 mL | 42.17 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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References
References are publications that support the products' biological activity.
Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405
Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981
Keywords: A 85380 dihydrochloride, supplier, A85380, dihydrochloride, high, affinity, selective, nicotinic, receptors, cholinergic, acetylcholine, alpha4beta2, a4b2, α4β2, agonists, Nicotinic, (a4b2), Receptors, Nicotinic, (a4b2), Receptors, Tocris Bioscience
