Biological Activity
Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
Technical Data
| M. Wt | 840.97 |
| Formula | C44H56N8O9 |
| Sequence |
XWKDF (Modifications: Trp-1 = Boc-Trp, Lys-3 = Lys(Tac), Phe-5 = N-methyl-Phe & C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 130408-77-4 |
| PubChem ID | 121964 |
| InChI Key | KNHCBYMGWWTGSO-ZYADHFCISA-N |
| Smiles | O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 20mM PBS buffer |
Preparing Stock Solutions
The following data is based on the product molecular weight 840.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.19 mL | 5.95 mL | 11.89 mL |
| 5 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 10 mM | 0.12 mL | 0.59 mL | 1.19 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951 PMID:
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346 PMID:
Keywords: A-71623, supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623, CCK1, Receptor, CCK1, Receptor, Tocris Bioscience
