Biological Activity
Positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo.
Compound Libraries
AA 29504 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 327.42 |
| Formula | C19H25N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 945828-50-2 |
| PubChem ID | 23188887 |
| InChI Key | SCOOTUMXCXKEAD-UHFFFAOYSA-N |
| Smiles | NC1=C(NC(OCC)=O)C=CC(NCC2=C(C)C=C(C)C=C2C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 327.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.27 mL | 30.54 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.11 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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References
References are publications that support the products' biological activity.
Hoestgaard-Jensen et al (2010) Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors. Neuropharmacology 58 702 PMID: 20060846
Keywords: AA 29504, supplier, GABAA, positive, allosteric, modulators, pams, alpha4beta3delta, a4b3d, α4β3γ, anxiolytic, gamma-aminobutyric, acid, AA29504, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
