Biological Activity
High affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).
Technical Data
| M. Wt | 240.3 |
| Formula | C15H16N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 924298-51-1 |
| PubChem ID | 11481862 |
| InChI Key | CNNZLFXCUQLKOB-BMRADRMJSA-N |
| Smiles | CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 12.02 | 50 | |
| DMSO | 24.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.16 mL | 20.81 mL | 41.61 mL |
| 5 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 10 mM | 0.42 mL | 2.08 mL | 4.16 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.83 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903 PMID: 17110115
Keywords: ABP 688, supplier, ABP688, metabotropic, glutamate, receptors, group, I, human, mGlu5, mGluR5, antagonists, antagonism, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
