BiologicalActivity
Potentandselectiveprotease-activatedreceptor2(PAR2)agonist(pEC50=7.5).DisplaysnoactivityatotherPARsubtypesandexhibitsnosignificantactivityatover30otherreceptorsimplicatedinnociceptionandinflammation.StimulatesPIhydrolysis,Ca2+mobilizationandcellularproliferationinvitro(pEC50valuesare6.9,7.0and7.5respectively).
CompoundLibraries
AC264613isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 400.27 |
| Formula | C19H18BrN3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1051487-82-1 |
| PubChemID | 25108278 |
| InChIKey | RQKXQCSEZPQBNZ-QSBCOWLBSA-N |
| Smiles | O=C1[C@@H]([C@](N/N=C(C)/C3=CC=CC(Br)=C3)=O)[C@H]([C@]2=CC=CC=C2)CN1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight400.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.49mL | 24.98mL |
| 5mM | 0.5mL | 2.5mL | 5mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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