Biological Activity
Highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).
Compound Libraries
(±)-AC 7954 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 366.28 |
| Formula | C19H20ClNO2.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 477313-09-0 |
| PubChem ID | 9907171 |
| InChI Key | AJPGLOWFIBOGMH-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CCC1(CC2=CC=CC=C2C(=O)O1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.47 | 75 | |
| ethanol | 18.31 | 50 | |
| water | 27.47 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 366.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.3 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Croston et al (2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 45 4950 PMID: 12408704
Lavecchia et al (2005) Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48 2480 PMID: 15801838
Lehmann et al (2006) Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 49 2232 PMID: 16570919
Keywords: (±)-AC 7954 hydrochloride, supplier, Non-peptide, UT, receptor, agonists, Receptors, Urotensin-II, (±)-AC7954, hydrochloride, Urotensin-II, Receptors, Urotensin-II, Receptors, Tocris Bioscience
