Tocris/ACHP/4547/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/ACHP/4547/10/10 mg

Tocris/ACHP/4547/10/10 mg

商品编号： 4547/10

品牌： Tocris Bioscience

市场价： ¥5300.00

美元价： 3180.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectiveIKKαandIKKβinhibitor

ChemicalName:2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

IκBkinaseinhibitor(IC₅₀valuesare8.5and250nMforIKKβandIKKαrespectively).SelectiveforIKKαandIKKβoverIKK3,SykandMAPKKK4(IC₅₀valuesare>20μM).InhibitsDNAbindingactivityofNF-κB.BlocksNF-κBpathwayinmultiplemyelomacelllines;inducescellgrowtharrestandapoptosis.

TechnicalData

M.Wt	364.44
Formula	C₂₁H₂₄N₄O₂
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	406208-42-2
PubChemID	65663
InChIKey	SRVFFFJZQVENJC-IHRRRGAJSA-N
Smiles	OC1=CC=CC(OCC3CC3)=C1C2=NC(N)=C(C#N)C(C4CCNCC4)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	7.29	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight364.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.74mL	13.72mL	27.44mL
5mM	0.55mL	2.74mL	5.49mL
10mM	0.27mL	1.37mL	2.74mL
50mM	0.05mL	0.27mL	0.55mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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TechnicalData

SolubilityData

PreparingStockSolutions

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