Biological Activity
Competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Licensing Information
Sold with the permission of the CNRS
Technical Data
| M. Wt | 217.18 |
| Formula | C8H11NO6 |
| Storage | Desiccate at -20°C |
| CAS Number | 195209-04-2 |
| PubChem ID | 5280961 |
| InChI Key | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Smiles | N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 5 mM in DMSO and to 100 mM in 1.4 eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.6 mL | 23.02 mL | 46.04 mL |
| 5 mM | 0.92 mL | 4.6 mL | 9.21 mL |
| 10 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600
Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, Non-selective, mGlu, Tocris Bioscience
