BiologicalActivity
Selectivefreefattyacidreceptor4(FFA4/GPR120)antagonist(pIC50valuesare7.1and<4.6forhumanFFA4andFFA1receptorsrespectively).InhibitslinoleicacidandGSK137647A-inducedintracellularcalciumaccumulationinU2OSosteosarcomacellsexpressingtheFFA4receptor.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
AH7614isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 351.42 |
| Formula | C20H17NO3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 6326-06-3 |
| PubChemID | 233085 |
| InChIKey | OZCQEUZTOAAWDK-UHFFFAOYSA-N |
| Smiles | CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight351.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.85mL | 14.23mL | 28.46mL |
| 5mM | 0.57mL | 2.85mL | 5.69mL |
| 10mM | 0.28mL | 1.42mL | 2.85mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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ProductDatasheets
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