BiologicalActivity
Cell-permeable,allostericactivatorofAMP-activatedproteinkinase(AMPK).Augmentsproliferation,differentiationandmineralizationofosteoblasticMC3T3-EIcellsandattenuatespsychosine-inducedexpressionofproinflammatorycytokinesandiNOSinastrocytes.PromotesosteogenicdifferentiationofhAMSCsandBM-MSCsinvitro.
CompoundLibraries
AICARisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 258.23 |
| Formula | C9H14N4O5 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 2627-69-2 |
| PubChemID | 17513 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=C2N)[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.37 | 75 | |
| water | 19.37 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight258.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.87mL | 19.36mL | 38.73mL |
| 5mM | 0.77mL | 3.87mL | 7.75mL |
| 10mM | 0.39mL | 1.94mL | 3.87mL |
| 50mM | 0.08mL | 0.39mL | 0.77mL |
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ProductDatasheets
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