BiologicalActivity
PotentAck1(TNK2)inhibitor(IC50=22nM).ExhibitsselectivityforAck1overABL1,BTK,LckandLYN;exhibitsnoinhibitionof25otherkinases.SuppressesphosphorylationofTyr267oftheandrogenreceptorinprostatecancercells.AlsosuppressesgrowthofrADIoresistantcastration-resistantprostatecancerinxenografttumorsinmice.
CompoundLibraries
AIM100isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.43 |
| Formula | C23H21N3O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 873305-35-2 |
| PubChemID | 11501591 |
| InChIKey | XNFHHOXCDUAYSR-SFHVURJKSA-N |
| Smiles | C1(C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)=C3N=CN=C1NC[C@H]2OCCC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.14 | 100 | |
| ethanol | 37.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.92mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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ProductDatasheets
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