Tocris/AMG 548/3920/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/AMG 548/3920/10/10 mg

Tocris/AMG 548/3920/10/10 mg

商品编号： 3920/10

品牌： Tocris Bioscience

市场价： ¥4980.00

美元价： 2988.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Potentandselectivep38αinhibitor

ChemicalName:2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofp38α(K_ivaluesare0.5,3.6,2600and4100nMforp38α,p38β,p38γandp38δrespectively).Displays>1000-foldselectivityagainst36otherkinases;inhibitswholebloodLPS-stimulatedTNFα(IC₅₀=3nM).Efficaciousinacuteandchronicmodelsofarthritis.

CompoundLibraries

AMG548isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	461.56
Formula	C₂₉H₂₇N₅O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	864249-60-5
PubChemID	11167112
InChIKey	RQVKVJIRFKVPBF-VWLOTQADSA-N
Smiles	O=C1N(C)C(NC[C@@H](N)CC5=CC=CC=C5)=NC(C4=CC=NC=C4)=C1C3=CC2=C(C=C3)C=CC=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	49.8	100
	ethanol	49.8	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight461.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.17mL	10.83mL	21.67mL
5mM	0.43mL	2.17mL	4.33mL
10mM	0.22mL	1.08mL	2.17mL
50mM	0.04mL	0.22mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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