BiologicalActivity
ThefirstselectivemGlu7agonist.PotentlyinhibitscAMPaccumulationandstimulatesGTPγSbindinginrecombinantcellsandonmembranesexpressingmGlu7(EC50=64-290nM).SelectiveoverothermGluRsubtypesandselectedionotropicglutamatereceptorsupto10μM.Actsviaanovelallostericsiteandisorallyactiveandbrainpenetrant.Reduceshaloperidol-inducedcatalepsyinrats.
ViewimportantinformationregardingtheusageofAMN082dihydrochloride.
CompoundLibraries
AMN082dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 465.45 |
| Formula | C28H28N2.2HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 97075-46-2 |
| PubChemID | 11698390 |
| InChIKey | YRQCDCNQANSUPB-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(CNC(C1=CC=CC=C1)C1=CC=CC=C1)NC(C1=CC=CC=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.55 | 100 | |
| water | 0.93 | 2mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight465.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.74mL | 21.48mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.21mL | 1.07mL | 2.15mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
