Biological Activity
Potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity="" over="" other="" ppar="" subtypes.="" increases="" abc="" a1="" transporter="" expression="" and="" induces="" apolipoprotein="" a1-mediated="" cholesterol="" efflux="">in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
Technical Data
| M. Wt | 453.5 |
| Formula | C21H18F3NO3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 317318-70-0 |
| PubChem ID | 9803963 |
| InChI Key | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| Smiles | CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=CC=C1OCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.35 | 100 | |
| ethanol | 22.68 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 453.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Oliver et al (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc.Natl.Acad.Sci.USA. 98 5306 PMID: 11309497
Ito et al (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354 1156 PMID: 27738012
Keywords: GW 501516, supplier, GW501516, Potent, selective, PPARδ, agonists, agonism, reverse, cholesterol, transporter, ATP-binding, cassette, A1, obesity, peroxisome, proliferator-activated, receptors, delta, PPARdelta, Receptors, PPARdelta, Receptors, Tocris Bioscience
