Biological Activity
Selective motilin receptor antagonist (pKd = 8.24). Exhibits no effect on acetylcholine, substance P or serotonin stimulated intestinal contraction.
Technical Data
| M. Wt | 1761.05 |
| Formula | C86H125N19O21 |
| Sequence | FVFIFTYGELQRLQ |
| Storage | Store at -20°C |
| CAS Number | 153966-48-4 |
| PubChem ID | 90489005 |
| InChI Key | YQKDYBMNXFOSLF-SDGXXZENSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1761.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 5 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 10 mM | 0.06 mL | 0.28 mL | 0.57 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.11 mL |
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References
References are publications that support the products' biological activity.
Depoortere et al (1995) Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur.J.Pharmacol. 286 241 PMID: 8608785
Peeters et al (1994) The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem.Biophys.Res.Commun. 198 411 PMID: 8297350
Keywords: ANQ 11125, supplier, ANQ11125, Motilin, receptor, antagonists, motilides, Motilin, Receptors, Motilin, Receptors, Tocris Bioscience
