BiologicalActivity
Potentmulti-kinaseandpan-Bcr-Ablinhibitor.DisplayspotentactivityagainstcelllinesexpressingnativeBcr-AblorBcr-AblT3151(IC50valuesare0.37and2.0nMrespectively);alsoinhibitsotherAblkinasedomainmutantsatnanomolarpotencies.ExhibitsinhibitoryactivityagainstPDGFRα,c-Srcandc-Kit(IC50valuesare1.1,5.4and12.5nMrespectively);potentlyinhibitsFGFRandVEGFRfamilykinases.Orallyactive.
CompoundLibraries
AP24534isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 532.56 |
| Formula | C29H27F3N6O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 943319-70-8 |
| PubChemID | 24826799 |
| InChIKey | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C(NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C1C#CC2=CN=C3N2N=CC=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.26 | 100 | |
| ethanol | 26.63 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight532.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.39mL | 18.78mL |
| 5mM | 0.38mL | 1.88mL | 3.76mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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