BiologicalActivity
AfunctionalandmembranepermeableD-myo-inositol1,4,5-trisphosphate(IP3)receptorantagonist(IC50=42μM).Stimulatesstore-operatedcalcium(SOC)releaseatlowconcentrations(<10μM)andinhibitsitathigherconcentrations(upto50μM).IncreasesSTIM-Oraichannelconductanceandlimitsionselectivity.ModulatorofTRPchannels;blocksTRPC1,TRPC3,TRPC5,TRPC6,TRPV6,TRPM3,TRPM7,TRPM8andTRPP2andathigherconcentrationsstimulatesTRPV1,TRPV2andTRPV3.Alsoblocksspecificgapchannelsubtypes.
TechnicalData
| M.Wt | 225.1 |
| Formula | C14H16BNO |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 524-95-8 |
| PubChemID | 1598 |
| InChIKey | BLZVCIGGICSWIG-UHFFFAOYSA-N |
| Smiles | NCCOB(C1=CC=CC=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.51 | 100mMwithgentlewarming | |
| ethanol | 2.25 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight225.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.44mL | 22.21mL | 44.42mL |
| 5mM | 0.89mL | 4.44mL | 8.88mL |
| 10mM | 0.44mL | 2.22mL | 4.44mL |
| 50mM | 0.09mL | 0.44mL | 0.89mL |
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ProductDatasheets
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