BiologicalActivity
SelectiveinhibitorofAkt(proteinkinaseB)signaling;displaysminimalinhibitionofPKC,PKA,SGKandp38pathways.InhibitsphosphorylationandactivationofdownstreamtargetsofAktincludingBad,GSK-3βandAFX.Inducesapoptosisandgrowtharrestinvitro,preferentiallyinhumancancercellswithelevatedlevelsofAkt.PotentlyandselectivelyinhibitsgrowthofAkt-overexpressingtumorsinmice.InhibitsDNAsynthesisanddisplaysantiviralactivityagainstHIV-1and-2.
CompoundLibraries
API-2isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 320.31 |
| Formula | C13H16N6O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 35943-35-2 |
| PubChemID | 65399 |
| InChIKey | HOGVTUZUJGHKPL-HTVVRFAVSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C3=C(C4=NC=N3)C(C(N)=NN4C)=C2)[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 32.03 | 100 | |
| DMSO | 32.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight320.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.12mL | 15.61mL | 31.22mL |
| 5mM | 0.62mL | 3.12mL | 6.24mL |
| 10mM | 0.31mL | 1.56mL | 3.12mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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ProductDatasheets
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