Biological Activity
Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.
Technical Data
| M. Wt | 257.18 |
| Formula | C10H12NO5P |
| Storage | Desiccate at +4°C |
| CAS Number | 170847-18-4 |
| PubChem ID | 4694355 |
| InChI Key | ZNQZXIHSJUDIKL-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1.1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 257.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.89 mL | 19.44 mL | 38.88 mL |
| 5 mM | 0.78 mL | 3.89 mL | 7.78 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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References
References are publications that support the products' biological activity.
Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188 PMID: 10712449
Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162 PMID: 11752112
Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195 PMID:
Keywords: (RS)-APICA, supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
