Biological Activity
A competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.
Technical Data
| M. Wt | 395.42 |
| Formula | C16H17N5.C4H4O4 |
| Storage | Desiccate at -20°C |
| CAS Number | 201216-42-4 |
| PubChem ID | 11567402 |
| InChI Key | UHLVYEOCPBNJNA-BTJKTKAUSA-N |
| Smiles | OC(=O)C=C/C(O)=O.C=CCN1CCN(CC1)C1=NC2=CC=CC=C2N=C1C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 395.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Buznikov et al (2005) The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 30 825 PMID: 16187217
Durk et al (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 17 599 PMID: 15802305
Monge et al (1993) Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 36 2745 PMID: 8410988
Keywords: 3-AQC, supplier, 5-HT3, antagonists, Serotonin, Receptors, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
