Biological Activity
Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 218.68 |
| Formula | C9H14N2O2.HCl |
| Storage | Desiccate at RT |
| CAS Number | 178419-42-6 |
| PubChem ID | 9859263 |
| InChI Key | XGLBLUBBDSJBIU-FVGYRXGTSA-N |
| Smiles | O=C(NC3)O[C@@]13CN2CCC1CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.93 | 50 | |
| water | 21.87 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 218.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.57 mL | 22.86 mL | 45.73 mL |
| 5 mM | 0.91 mL | 4.57 mL | 9.15 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.57 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.91 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Grottick et al (2000) Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J.Pharmacol.Exp.Ther. 294 1112 PMID: 10945867
Mullen et al (2000) (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. J.Med.Chem. 43 4045 PMID: 11063601
Huang et al (2010) Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br.J.Pharmacol. 159 554 PMID: 20105181
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