Tocris/AS 2444697/5430/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/AS 2444697/5430/50/50 mg

Tocris/AS 2444697/5430/50/50 mg

商品编号： 5430/50

品牌： Tocris Bioscience

市场价： ¥19300.00

美元价： 11580.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveIRAK4inhibitor

ChemicalName:N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamidehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinterleukin-1receptor-associatedkinase4(IRAK4)inhibitor(IC₅₀=21nM).Displays30-foldselectivityforIRAK4overIRAK1.InhibitsLPS-inducedTNF-αandIL-6productioninPBMCsinvitro.Renoprotectiveandanti-inflammatoryinarodentmodelofchronickidneydisease.

CompoundLibraries

AS2444697isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	432.86
Formula	C₁₉H₂₀N₆O₄.HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	1287665-60-4
PubChemID	118719434
InChIKey	FGNHLIIFEDYNFZ-UHFFFAOYSA-N
Smiles	O=C(N)C2=NN(C=C2NC(C3=COC(C4=CC=NC(C)=C4)=N3)=O)C1CCOCC1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	43.29	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight432.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.31mL	11.55mL	23.1mL
5mM	0.46mL	2.31mL	4.62mL
10mM	0.23mL	1.16mL	2.31mL
50mM	0.05mL	0.23mL	0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets