BiologicalActivity
Potentanaplasticlymphomakinase(ALK)inhibitor(IC50=3.5nM).AlsoinhibitsAckandROS1activity(IC50valuesare5.8and8.9nMrespectively).Attenuatesproliferation,andinducesapoptosisofNPM-ALK+Tcellanaplasticlarge-celllymphoma(ALCL)cellsinvitro.SuppressestumorgrowthofNPM-ALK+ALCLcellxenograftsinmice.CausestumorshrinkageinhEML4-ALKtransgenicmice.Orallyavailable.
CompoundLibraries
ASP3026isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 580.74 |
| Formula | C29H40N8O3S |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1097917-15-1 |
| PubChemID | 25134326 |
| InChIKey | MGGBYMDAPCCKCT-UHFFFAOYSA-N |
| Smiles | CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.61 | 20 | |
| ethanol | 2.9 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight580.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.72mL | 8.61mL | 17.22mL |
| 5mM | 0.34mL | 1.72mL | 3.44mL |
| 10mM | 0.17mL | 0.86mL | 1.72mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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