BiologicalActivity
PotentandselectiveERK5inhibitor(IC50=8nM).Exhibits>1,000-foldselectivityforERK5overapanelofover200kinases.AlsoexhibitsselectivityoverbromodomainBRD4(Kd=3,600nM).Increasesvomocytosisinhumanmacrophagesinvitro,aswellasinaninvivozebrafishmodelofcryptococcaldisease,reducingspreadofinfection.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofAX15836isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 648.78 |
| Formula | C32H40N8O5S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 122705989 |
| InChIKey | HTFNVAVTYILUCF-UHFFFAOYSA-N |
| Smiles | CCOC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C3=N2)S(C)(=O)=O)C=CC(=C1)C(=O)N1CCC(CC1)N1CCN(C)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 64.88 | 100 | |
| DMSO | 64.88 | 100 | |
| ethanol | 64.88 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight648.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.54mL | 7.71mL | 15.41mL |
| 5mM | 0.31mL | 1.54mL | 3.08mL |
| 10mM | 0.15mL | 0.77mL | 1.54mL |
| 50mM | 0.03mL | 0.15mL | 0.31mL |
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