Biological Activity
Selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.
Technical Data
| M. Wt | 680.8 |
| Formula | C34H48N8O7 |
| Sequence |
AYPGKF (Modifications: Phe-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 352017-71-1 |
| PubChem ID | 9987061 |
| InChI Key | BBAOHIALRKLBRD-OZDPOCAXSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.47 mL | 7.34 mL | 14.69 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 10 mM | 0.15 mL | 0.73 mL | 1.47 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728 PMID: 10779527
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Keywords: AY-NH2, supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, AYPGKF-NH2, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
