Tocris/AZ 10397767/5872/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/AZ 10397767/5872/10/10 mg

Tocris/AZ 10397767/5872/10/10 mg

商品编号： 5872/10

品牌： Tocris Bioscience

市场价： ¥4180.00

美元价： 2508.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentCXCR2antagoNIST

ChemicalName:5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentCXCR2antagonist(IC₅₀=1nM);attenuatesoxaliplatin-inducedNF-κBactivation,increasesoxaliplatincytotoxicity,andpotentiatesoxaliplatin-inducedapoptosisinAIPCcells.Reducesthenumbersofneutrophilsinfiltratingintotumorsinbothinvitroandinvivomodelsanddelayedtumorgrowth.Orallybioavailable.

CompoundLibraries

AZ10397767isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	400.88
Formula	C₁₅H₁₄ClFN₄O₂S₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	333742-63-5
PubChemID	11858154
InChIKey	KHTUORKUWBDRBX-SSDOTTSWSA-N
Smiles	C[C@@H](NC1=C2SC(NC2=NC(SCC3=C(C(Cl)=CC=C3)F)=N1)=O)CO

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	40.09	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight400.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.49mL	12.47mL	24.95mL
5mM	0.5mL	2.49mL	4.99mL
10mM	0.25mL	1.25mL	2.49mL
50mM	0.05mL	0.25mL	0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets