Tocris/AZ 10417808/2172/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/AZ 10417808/2172/10/10毫克

Tocris/AZ 10417808/2172/10/10毫克

商品编号： 2172/10

品牌： Tocris Bioscience

市场价： ¥3980.00

美元价： 2388.00

产地：美国(厂家直采)

公司：

产品分类：蛋白酶类

公司分类： protease

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:Selectivenon-peptidecaspase-3inhibitor

AlternativeNames:AQZ-1

ChemicalName:2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivenon-peptideinhibitorofcaspase-3(K_i=247nM);displays>40-foldselectivityovercaspases1,2,6,7and8(K_i>10μM).Completelyblocksstaurosporine-inducedintracellularDEVDaseactivityinSH-SY5Ycells(IC₅₀=14.9μM).

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

AZ10417808isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	434.23
Formula	C₁₈H₁₃Cl₂N₅O₄
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	331645-84-2
PubChemID	16759160
InChIKey	VUBILPOZTRGZJK-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=CC2=C(N=C(NC3=CC(Cl)=C(Cl)C=C3)NC2=O)C(=C1)C(=O)NCC=C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	10.86	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight434.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.3mL	11.51mL	23.03mL
5mM	0.46mL	2.3mL	4.61mL
10mM	0.23mL	1.15mL	2.3mL
50mM	0.05mL	0.23mL	0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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