BiologicalActivity
PotentP2X7receptorantagonist(KDvaluesare1.4and19nMathumanandratP2X7receptorsrespectively).Bindsinapositivecooperativemannertositesdistinctfrom,butcoupledto,theATPbindingsiteandactsasanegativeallostericmodulator.Inhibitstumorgrowthanddisplaysantiangiogeniceffectsinmice.
LicensingInformation
SoldforresearchpurposesunderagreementfromAstraZeneca
CompoundLibraries
AZ10606120dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 495.48 |
| Formula | C25H34N4O2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 607378-18-7 |
| PubChemID | 56972227 |
| InChIKey | BVFONFUUWORSPO-UHFFFAOYSA-N |
| Smiles | O=C(NC4=C(C=CC(NCCNCCO)=N5)C5=CC=C4)CC1(C3)CC2CC(CC3C2)C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.55 | 100 | |
| water | 12.39 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight495.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.02mL | 10.09mL | 20.18mL |
| 5mM | 0.4mL | 2.02mL | 4.04mL |
| 10mM | 0.2mL | 1.01mL | 2.02mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
