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当前位置: 首页 > 产品中心 > Signal_pathway > Tocris/AZ 10606120二氢氯化物/3323/50/50毫克
商品详细Tocris/AZ 10606120二氢氯化物/3323/50/50毫克
Tocris/AZ 10606120二氢氯化物/3323/50/50毫克
Tocris/AZ 10606120二氢氯化物/3323/50/50毫克
商品编号: 3323/50
品牌: Tocris Bioscience
市场价: ¥14100.00
美元价: 8460.00
产地: 美国(厂家直采)
公司:
产品分类: 信号通路
公司分类: Signal_pathway
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:PotentP2X7receptorantagoNIST
ChemicalName:N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentP2X7receptorantagonist(KDvaluesare1.4and19nMathumanandratP2X7receptorsrespectively).Bindsinapositivecooperativemannertositesdistinctfrom,butcoupledto,theATPbindingsiteandactsasanegativeallostericmodulator.Inhibitstumorgrowthanddisplaysantiangiogeniceffectsinmice.

LicensingInformation

SoldforresearchpurposesunderagreementfromAstraZeneca

CompoundLibraries

AZ10606120dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt495.48
FormulaC25H34N4O2.2HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber607378-18-7
PubChemID56972227
InChIKeyBVFONFUUWORSPO-UHFFFAOYSA-N
SmilesO=C(NC4=C(C=CC(NCCNCCO)=N5)C5=CC=C4)CC1(C3)CC2CC(CC3C2)C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO49.55100
water12.3925

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight495.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.02mL10.09mL20.18mL
5mM0.4mL2.02mL4.04mL
10mM0.2mL1.01mL2.02mL
50mM0.04mL0.2mL0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet