Biological Activity
Positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.
Technical Data
| M. Wt | 392.35 |
| Formula | C19H22BrNOS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1290628-31-7 |
| PubChem ID | 73755190 |
| InChI Key | QKUYZJOTWYRWNF-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.23 | 100 | |
| ethanol | 39.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.49 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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References
References are publications that support the products' biological activity.
Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38 PMID:
Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50 PMID: 21382421
Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168 PMID: 20385173
Keywords: AZ 12216052, supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
